Анотація
In this work, the FeEDDSNP nanocomplex was synthesized by dissolution peptization of a freshly precipitated sol of iron hydroxide Fe(OH)3 in an aqueous solution of the racemic form of Н4EDDS. The complex was characterized by electron absorption spectroscopy and IR spectroscopy. It was shown that the structure of the nanocomplex is identical to the structure of the FeEDDS complex obtained using a two-stage technology. The position of the absorption maxima of iron nanoparticles practically does not change depending on the storage time at room temperature, which indicates the stability of the synthesized nanocomplex. The nanodispersed FeEDDSNP complex is more soluble in water (275 g/l) compared to the FeEDDS complex obtained by the classical method (150 g/l), which greatly facilitates its use as a biologically active compound. To determine the stability of the system depending on the pH, the electrokinetic potential was measured to select the optimal pH of the medium and concentrations to obtain stable dispersed systems. It is shown that at low pH (1.5–4.0) there is a drop in the electrokinetic potential, and when the pH increases, the
Посилання
Nose Y., Kim B. E., Thiele D. J. Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism and neonatal cardiac function. Cellmetabolism. 2006 4(3): 235–244.
https://doi.org/10.1016/j.cmet.2006.08.009.
Mikulewicz M., Chojnacka K., Kawala B., Gredes T. Trace Elementsin Living Systems: From Beneficial to Toxic Effects. Bio. Med. Research. International. 2017. (1–2)
https://doi.org/10.1155/2017/8297814.
Gumienna-Kontecka E., Rowińska-Żyrek M., Łuczkowski M. The Role of Trace Elements in Living Organisms. Recent Advances in Trace Elements. 2018: 177–206.
https://doi.org/10.1002/9781119133780.ch9.
Mazurenko E.A., Trunova E.K. Biologically active complexes based on succinic acid. Ukr. Chem. J. 2001. 67(7): 24. [in Russian].
Trunova E., Rogovtsov A., Mazurenko E., Shtemenko N., Makotrik T. Photochemical activity of complexes of Mn(II) with ethylenediaminedisuccinic acid. Ukr. Chem. J. 2001. 67(1): 7. [in Russian].
Goos R.J., Germain S. Solubility of twelve iron fertilizer products in alkaline soils. Communications in soil science and plant analysis. 2001. 32(13–14): 2317–2323.
https://doi.org/10.1081/CSS-1200002867.
Yiannikouris A., Connolly C., Power R., Lobinski R. Characterization of metal–peptide complexes in feed supplements of essential trace elements. Metallomics. 2009. 1(3): 235–248.
https://doi.org/10.1039/b901406c.
Costa N.J., Bombardieri C.R., Kuribayashi J.S., de Camargo M.M., Andrade L.H., Kagohara E., Espósito B.P. Antimicrobial Activity of Ethylenediaminedisuccinate Metal Complexes. Short Communication. Chemistry & Biodiversity. 2008. 5(10): 2156–2159.
https://doi.org/10.1002/cbdv.200890196).
Vogel J.U., Michaelis M., Neyts J., Blaheta R.A., Snoeck R., Andre, G., ... & Doerr H. W. Antiviral and immunomodulatory activity of the metal chelator ethylenediaminedisuccinic acid against cytomegalovirus in vitro and in vivo. Antiviral research. 2002. 55(1): 179–188.
https://doi.org/10.1016/S0166-3542(02)00025-6.
Race M., Ferraro A., Fabbricino M., La Marca A., Panico A., Spasiano D., ... & Pirozzi F. Ethylenediamine-N,N′-disuccinic acid (EDDS) – enhanced flushing optimization for contaminated agricultural soil remediation and assessment of prospective Cu and Zn transport. International journal of environmental research and public health. 2018. 15(3): 543.
https://doi.org/10.3390/ijerph15030543.
Edenhart S., Denneler M., Spohn M., Doskocil E., Kavšček M., Amon, T., ...& Stegmann E. Metabolic engineering of Amycolatopsis japonicum for optimized production of [S, S]-EDDS, a biodegradable chelator. Metabolic engineering. 2020. 60: 148–156.
https://doi.org/10.1016/j.ymben.2020.04.003.
Nikulina E.A., Akimova S.V., Tsirulnikova N.V., Glinushkin A.P., Dolgoborodov I.O., Kirkach V.V. Screening of different Fe(II) and Fe(III) complexes at the stage of rhizogenesis in vitro of gooseberry plants. In Journal of Physics: Conference Series. 2021. 1942 (1): 012075.
https://doi.org/10.1088/1742-6596/1942/1/ 012075.
Paton B., Moskalenko V., Chekman I., Movchan B. Nanoscience and nanotechnologies: technical, medical, social aspects. Visnyk of the National Academy of Sciences of Ukraine. 2009. 6: 18–26.
http://dspace.nbuv.gov.ua/handle/123456789/ 26128.
Rizzello L., Pompa P.P. Nanosilver-based antibacterial drugs and devices: mechanisms, methodological drawbacks, and guidelines. Chem. Soc. Rev. 2014. 43 (5): 1501–1518.
https://doi.org/10.1039/c3cs60218d.
Sanvicens N., Marco M.P. Multifunctional nanoparticles - properties and prospects for their use in human medicine. Trends Biotechnol. 2008. 26: 425–433.
https://doi.org/10.1016/j.tibtech.2008.04.005.
Jeevanandam J., Barhoum A., Chan Y. S., Dufresne A., Danquah M.K. Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein journal of nanotechnology, 2018. 9(1): 1050–1074.
https://doi.org/10.3762/bjnano.9.98.
Li H., Kang Z., Liu Y., Lee S.T. Carbon nanodots: synthesis, properties and applications. Journal of materials chemistry. 2012. 22(46): 24230–24253.
https://doi.org/10.1039/c2jm34690g.
Romashkina R.B., Beloglazkina E.K., Khlobystov A.N., Majouga A.G.,Pichugina D.A., Terenin V.I., Zyk N.V., Zefirov N.S. Copper (ІІ) coordination compounds as building blocks for the formation of gold nanoparticle dimers. Mendeleev Communications. 2011. 21. (3): 129–131.
https://doi.org/10.1016/j.mencom.2011.04. 004 30.
Zhang X., Li D., Zhou X. P. From large 3D assembly to highly dispersed spherical assembly: weak and strong coordination mediated self-aggregation of Au colloids. New Journal of Chemistry. 2006. 30(5): 706–711.
https://doi.org/10.1039/B515501K.
Viudez A. J., Madueño R., Pineda T., Blázquez M. Stabilization of gold nanoparticles by 6-mercaptopurine monolayers. Effects of the solvent properties. J. Phys.Chem. B. 2006. 110(36): 17840–17847.
https://doi.org/10.1021/jp062165l.
Liu J., Hurt R.H. Ion release kinetics and particle persistence in aqueous nano-silver colloids. Environmental science & technology. 2010. 44(6): 2169–2175.
https://doi.org/10.1021/es9035557.
Moellering R.C.JR. Discovering new antimicrobial agents. Review. International journal of antimicrobial agents. 2011. 37: 2–9.
https://doi.org/10.1016/j.ijantimicag.2010.08. 018.
Vertelov G.K., Krutyakov Y.A., Efremenkova O.V., Olenin A.Y., Lisichkin G.V. A versatile synthesis of highly bactericidal Myramistin® stabilized silver nanoparticles. Nanotechnolog. 2008. 19(35): 355–707.
https://doi.org/10.1088/0957-4484/19/35/355 707.
Mahmoud W.H., Deghadi R.G., ElDesssouky M.M., Mohamed G.G. Transition metal complexes of nano bidentate organometallic Schiff base: Preparation, structure characterization, biological activity, DFT and molecular docking studies. Applied Organometallic Chemistry. 2019. 33(1): 4556.
https://doi.org/10.1002/aoc.4556.
Taha R. H. Synthesis and Characterization of Nanocomplexes by Green Chemistry and Their Applications in Different Fields. In Green Chemistry Applications. 2019. IntechOpen.
https://doi.org/10.5772/intechopen.83558.
Wei F., Chen Z., Shen X.C., Ji L., Chao H. Recent progress in metal complexes functionalized nanomaterials for photodynamic therapy. Chem. Commun. 2023. 59: 6956–6968.
https://doi.org/10.1039/D3CC01355C.
Majer J., Springer V., Kopecka B. Nove komplexany (VIII). Kyselina ethylendiamin-N,N-dijantarova a spektrofotometricke studium jej komplexov s tazkymi kovmi. Chem. Zvesti. 1966. 20(6): 414–422.
Oftring A., Ott C., Potthoff-Karl B. Method for producing (S,S)-N,N'-ethylenediaminedisuccinic acid, analogous compounds or salt thereof. U.S. Patent No. 6,437,181. Washington, DC: U.S. Patent and Trademark Office (2002).
Putaux J.L., Lancelon-Pin C., Legrand F.X., Pastrello M., Choisnard L., Geze A., ... & Wouessidjewe D. Self-assembly of amphiphilic biotransesterified β-cyclodextrins: supramolecular structure of nanoparticles and surface properties. Langmuir. 2017. 33(32): 7917–7928.
https://doi.org/10.1021/acs.langmuir.7b01136.
Dozol H., Mériguet G., Ancian B., Cabuil V., Xu H., Wang D., Abou-Hassan A. On the Synthesis of Au Nanoparticles Using EDTA as a Reducing Agent. Phys. Chem. C. 2013. 117(40): 20958–20966.
https://doi.org/10.1021/jp4067789.
Liver E. Electronic spectroscopy of inorganic compounds. (Moscow: Мir, 1987). [in Russian].
Lanigan K.C., Pidsosny K. Reflectance FTIR spectroscopic analysis of metal complexation to EDTA and EDDS. Vibrational Spectroscopy. 2007. 45(1): 2–9.
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