The article is devoted to the history and present of the Institute of Organic Chemistry of NAS of Ukraine. By Boris Paton's definition, the Institute of Organic Chemistry belongs to the memorial institutions of the National Academy of Sciences of Ukraine. On May 23, 1939, the Presidium of the USSR Academy of Sciences, according to resolution of the Council of People's Commissars of the USSR (May 8, 1939) decided to set up the Institute of Organic Chemistry and Technology of the USSR Academy of Sciences and the Institute of Organic Chemistry of the Ukrainian Academy of Sciences. There were four scientific departments in the Institute, headed by academicians of the Academy of Sciences of the Ukrainian SSR: General Organic Synthesis - V.P. Jaworski, fuel - M.I. Kuznetsov, macromolecular compounds - I.K. Matsurevich, fibrous substances and dyes - V.G. Shaposhnikov at the time of its foundation. V. P. Jaworski, the academician of the Academy of Sciences of the Ukrainian SSR, was the first Director of the Institute. Since the institute's existence, such outstanding scientists have worked in the institution as: Andrei Kiprianov (founder of the color theory of organic dyes, phenomenon of interaction of chromophores "Phenomenon AI Kiprianov", VM Zubarovsky, OI Tolmachov, Yu.L. Slominsky, OO Ishchenko, KD Sych, IK Ushenko, FA (development of preparative chemistry of thiazole, benzothiazole, benzimidazole and a number of heterocycles), E.O. Shilov (formation of p-complexes of molecules of unsaturated compounds with electrophilic reagents, substantiation of mechanisms of biochemical processes), OA Yasnikov (theory of radical transformations in reactions modeling nicotinamide coenzymes, open catalytic properties of cytochrome production technology for phospho-rylated starch), OV Kirsanov (reaction of amino compounds with phosphorus pentachloride and reaction of oxidative imination of compounds of trivalent phosphorus with dichloramines), A.F. Plate, IL Knunanciec, M.I. Kabachnik, L.M. Markovsky (Chemistry of Sulfur Organic Com-pounds) and VP Kuchar (Works on Chemistry of Phosphorus Organic Compounds), Yu. Gololobov (Chemistry of Organo-Organic Compounds), A.D. Sinitsa (Methods of Synthesis and Investigation of the Properties of Imino-Phosphonates), OI Kolodyazhny (Chemistry of Phosphorus Illides), L.M. Yagupolsky (Yagupolsky principle, Buchwald – Hartwig – Yagupolsky reaction), M.O. Lozynsky, S.V. Komisarenko (chemistry of physiologically active heterocyclic compounds), V.I. Kalchenko (molecular design, synthesis and study of supramolecular interactions of macrocyclic compounds - crowneters, calixarenes, thiacalixarenes and calixresorbins). The Institute's developments have great innovation potential today. The Institute's staff published 8,000 scientific articles, 90 monographs and obtained 1550 copyright certificates and patents. The Institute has trained 350 candidates and 65 doctors of science during its work.